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Curr Opin Microbiol. 2011 Oct;14(5):519-23. doi: 10.1016/j.mib.2011.08.003. Epub 2011 Sep 6.

Combination therapies for combating antimicrobial resistance.

Author information

1
Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA. fischbach@fischbachgroup.org

Abstract

New drug development strategies are needed to combat antimicrobial resistance. The object of this perspective is to highlight one such strategy: treating infections with sets of drugs rather than individual drugs. We will highlight three categories of combination therapy: those that inhibit targets in different pathways; those that inhibit distinct nodes in the same pathway; and those that inhibit the very same target in different ways. We will then consider examples of naturally occurring combination therapies produced by micro-organisms, and conclude by discussing key opportunities and challenges for making more widespread use of drug combinations.

PMID:
21900036
PMCID:
PMC3196371
DOI:
10.1016/j.mib.2011.08.003
[Indexed for MEDLINE]
Free PMC Article

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