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Nano Lett. 2011 Oct 12;11(10):4411-4. doi: 10.1021/nl2025882. Epub 2011 Sep 14.

Nanoparticles targeting the infarcted heart.

Author information

1
Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

Abstract

We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.

PMID:
21899318
PMCID:
PMC3192253
DOI:
10.1021/nl2025882
[Indexed for MEDLINE]
Free PMC Article

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