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Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):51-78. doi: 10.1002/wsbm.159. Epub 2011 Sep 2.

Normal morphogenesis of epithelial tissues and progression of epithelial tumors.

Author information

1
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.

Abstract

Epithelial cells organize into various tissue architectures that largely maintain their structure throughout the life of an organism. For decades, the morphogenesis of epithelial tissues has fascinated scientists at the interface of cell, developmental, and molecular biology. Systems biology offers ways to combine knowledge from these disciplines by building integrative models that are quantitative and predictive. Can such models be useful for gaining a deeper understanding of epithelial morphogenesis? Here, we take inventory of some recurring themes in epithelial morphogenesis that systems approaches could strive to capture. Predictive understanding of morphogenesis at the systems level would prove especially valuable for diseases such as cancer, where epithelial tissue architecture is profoundly disrupted.

PMID:
21898857
PMCID:
PMC3242861
DOI:
10.1002/wsbm.159
[Indexed for MEDLINE]
Free PMC Article

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