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Free Radic Res Commun. 1990;9(2):101-12.

Induction of haem oxygenase as a defence against oxidative stress.

Author information

1
Heart Research Institute, Camperdown NSW, Australia.

Abstract

Cells respond to metabolic perturbations by producing specific stress proteins. Exposure of mammalian cells to various forms of oxidative stress induces haem oxygenase, the rate-limiting enzyme in haem degradation. This response is proposed to represent an antioxidant defence operating at two different stages simultaneously. It (i) decreases the levels of the potential pro-oxidants haem and haem proteins such as cytochrome P-450 and protoporphyrinogen oxidase, and (ii) increases the tissue concentrations of antioxidatively active bile pigments.

PMID:
2189794
[Indexed for MEDLINE]

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