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Nat Rev Neurosci. 2011 Sep 7;12(10):585-601. doi: 10.1038/nrn3085.

A pathophysiological framework of hippocampal dysfunction in ageing and disease.

Author information

1
Department of Neurology, and The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th St, P&S 16. New York, New York 10032, USA.

Abstract

The hippocampal formation has been implicated in a growing number of disorders, from Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the hippocampal formation, a complex circuit that spans the temporal lobes, be involved in a range of such phenotypically diverse and mechanistically distinct disorders? Recent neuroimaging findings indicate that these disorders differentially target distinct subregions of the hippocampal circuit. In addition, some disorders are associated with hippocampal hypometabolism, whereas others show evidence of hypermetabolism. Interpreted in the context of the functional and molecular organization of the hippocampal circuit, these observations give rise to a unified pathophysiological framework of hippocampal dysfunction.

PMID:
21897434
PMCID:
PMC3312472
DOI:
10.1038/nrn3085
[Indexed for MEDLINE]
Free PMC Article

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