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Int J Sport Nutr Exerc Metab. 2011 Aug 29. [Epub ahead of print]

N-Acetylcysteine Attenuates Fatigue Following Repeated-Bouts of Intermittent Exercise: Practical Implications for Tournament Situations.

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1
School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.

Abstract

Production of reactive oxygen species (ROS) during contractions is associated with muscular fatigue and damage in the short-term and adaptive responses in the long-term. When adaptation is inconsequential acute antioxidant supplementation may be able to attenuate muscle fatigue and damage to enhance performance. This study aimed to determine the effects of acute oral N-acetylcysteine (NAC) supplementation on Yo-Yo intermittent recovery test performance level one (YIRT-L1) following repeated-bouts of damaging intermittent exercise. In a pair-matched design, twelve recreationally-trained males engaged in either six days of NAC (n = 6) or placebo (n = 6) supplementation. Following a treatment loading day, participants completed three testing sessions, on alternate days, consisting of a pre-exercise Isokinetic dynamometry (IKD) test, a damaging intermittent exercise protocol, YIRT-L1 and a post-exercise IKD. A further IKD test was completed on the two intervening days. NAC treatment resulted in a significant preservation of YIRT-L1 performance (P≤0.0005). IKD performance significantly deteriorated over time at all contractions speeds and this deterioration was not influenced by treatment group. Plasma creatine kinase values increased significantly over time (P=.002) and were significantly greater in the NAC group compared with the placebo group (P=.029). NAC induced mild-gastrointenstinal side effects. NAC supplementation may be a useful strategy to enhance performance during short-term competitive situations where adaption is inconsequential. Titration studies to elucidate a treatment dose that enhances performance without inducing side-effects are now required.

PMID:
21896942

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