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Ann Med. 2012 Nov;44(7):694-716. doi: 10.3109/07853890.2011.585658. Epub 2011 Sep 7.

Nitric oxide: orchestrator of endothelium-dependent responses.

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1
Institut Recherches Servier, Suresnes, France. michel.feletou@fr.netgrs.com

Abstract

The present review first summarizes the complex chain of events, in endothelial and vascular smooth muscle cells, that leads to endothelium-dependent relaxations (vasodilatations) due to the generation of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) and how therapeutic interventions may improve the bioavailability of NO and thus prevent/cure endothelial dysfunction. Then, the role of other endothelium-derived mediators (endothelium-derived hyperpolarizing (EDHF) and contracting (EDCF) factors, endothelin-1) and signals (myoendothelial coupling) is summarized also, with special emphasis on their interaction(s) with the NO pathway, which make the latter not only a major mediator but also a key regulator of endothelium-dependent responses.

PMID:
21895549
DOI:
10.3109/07853890.2011.585658
[Indexed for MEDLINE]
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