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Neurology. 2011 Sep 6;77(10):1005-12. doi: 10.1212/WNL.0b013e31822cfc90.

Incidence of epilepsy: a systematic review and meta-analysis.

Author information

1
Centre for Geographic Medicine Research-Coast, KEMRI, Kilifi 80108, Kenya. angugi@kilifi.kemri-wellcome.org

Abstract

OBJECTIVE:

To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates.

METHODS:

We searched online databases for incidence studies and used meta-analytic methods to analyze the data.

RESULTS:

Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04).

CONCLUSION:

We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.

PMID:
21893672
PMCID:
PMC3171955
DOI:
10.1212/WNL.0b013e31822cfc90
[Indexed for MEDLINE]
Free PMC Article

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