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Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12;366(1579):2759-65. doi: 10.1098/rstb.2011.0096.

Progress in the rational design of an AIDS vaccine.

Author information

1
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC 3005, Bethesda, MD 20892, USA. gnabel@mail.nih.gov

Abstract

Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requisite breadth and potency against circulating strains of HIV-1.

PMID:
21893538
PMCID:
PMC3146778
DOI:
10.1098/rstb.2011.0096
[Indexed for MEDLINE]
Free PMC Article

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