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Philos Trans A Math Phys Eng Sci. 2011 Oct 13;369(1952):3768-84. doi: 10.1098/rsta.2011.0081.

Assessing interactions in the brain with exact low-resolution electromagnetic tomography.

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The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Lenggstrasse 31, 8032 Zurich, Switzerland.


Scalp electric potentials (electroencephalogram; EEG) are contingent to the impressed current density unleashed by cortical pyramidal neurons undergoing post-synaptic processes. EEG neuroimaging consists of estimating the cortical current density from scalp recordings. We report a solution to this inverse problem that attains exact localization: exact low-resolution brain electromagnetic tomography (eLORETA). This non-invasive method yields high time-resolution intracranial signals that can be used for assessing functional dynamic connectivity in the brain, quantified by coherence and phase synchronization. However, these measures are non-physiologically high because of volume conduction and low spatial resolution. We present a new method to solve this problem by decomposing them into instantaneous and lagged components, with the lagged part having almost pure physiological origin.

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