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Trends Parasitol. 2011 Nov;27(11):487-95. doi: 10.1016/j.pt.2011.08.001. Epub 2011 Sep 3.

Toxoplasma gondii effectors are master regulators of the inflammatory response.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Toxoplasma is a highly successful parasite that establishes a life-long chronic infection. To do this, it must carefully regulate immune activation and host cell effector mechanisms. Here we review the latest developments in our understanding of how Toxoplasma counteracts the immune response of the host, and in some cases provokes it, through the use of specific parasite effector proteins. An emerging theme from these discoveries is that Toxoplasma effectors are master regulators of the pro-inflammatory response, which elicits many of the toxoplasmacidal mechanisms of the host. We speculate that combinations of these effectors present in certain Toxoplasma strains work to maintain an optimal parasite burden in different hosts to ensure parasite transmission.

PMID:
21893432
PMCID:
PMC3200456
DOI:
10.1016/j.pt.2011.08.001
[Indexed for MEDLINE]
Free PMC Article

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