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Am J Obstet Gynecol. 2011 Dec;205(6):537.e1-6. doi: 10.1016/j.ajog.2011.06.100. Epub 2011 Jul 13.

Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis.

Author information

1
Division of Interventional Radiology, Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305-5642, USA.

Abstract

OBJECTIVE:

The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk.

STUDY DESIGN:

This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors.

RESULTS:

DVT was associated with COC use (P = .022) and with increasing degrees of common iliac vein stenosis (P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase (P = .01).

CONCLUSION:

Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications.

PMID:
21893308
DOI:
10.1016/j.ajog.2011.06.100
[Indexed for MEDLINE]

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