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Vaccine. 2011 Nov 8;29(48):9093-7. doi: 10.1016/j.vaccine.2011.08.094. Epub 2011 Sep 3.

Do the initial serum level changes of sCD26 have ability to predict successful treatment with IFN-α among naïve chronic hepatitis B patients?

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Research Institute of Gastroenterology and Liver Diseases, Shahid Beheshti University, M.C, Tehran, Iran.



Hepatitis B is a major health problem with serious consequences. In hepatitis B treatment host cellular immune responses have a determinant role and T helper cells are the main active members of immune system against virological infection. The aims of this study are to investigate response rate of patients to INF-α therapy and evaluation of sCD26 and sCD30 roles as presenters of T cells activities in predicting the outcome of therapy in chronic hepatitis B patients.


Fifty three chronic hepatitis B patients received IFN-α 9 MU S.C three times weekly for 24 weeks, and were followed up for 24 weeks. Serum levels of sCD26 and sCD30, before, 1 and 3 months after treatment commencement were evaluated in 53 chronic hepatitis B patients and 30 healthy individuals as control group.


Normal level of ALT was seen in 64.1% (34/53) of patients and undetectable DNA was observed in 39.6% (21 out of 53) of them. Finally, 33.9% (18/53) of patients obtained sustain virological response. CD26 levels changes was correlated with response to treatment and significantly (p<0.001) increased during first 3 months of treatment among patients with successful response to therapy.


Interferon is an effective and safe treatment for chronic hepatitis B patients and sCD26 serum level changes might be useful in predicting the outcome of therapy in naïve chronic hepatitis B patients undergoing treatment with IFN-α, as it can help clinicians for withdrawing non-responder patients for prevention of adverse events and economical burden.

[Indexed for MEDLINE]

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