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Nat Cell Biol. 2011 Sep 2;13(9):1026-7. doi: 10.1038/ncb2334.

Coupling mitochondrial and cell division.

Abstract

The mitochondrial network fragments during mitosis to allow proper segregation of the organelles between daughter cells. Two mitotic kinases, the cyclin B-CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.

PMID:
21892144
PMCID:
PMC4762044
DOI:
10.1038/ncb2334
[Indexed for MEDLINE]
Free PMC Article

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