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Med Mycol J. 2011;52(3):229-37.

[Study on the usefulness of rinse containing miconazole nitrate for treatment of dandruff--a double-blind, comparative study].

[Article in Japanese]

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Department of Dermatology, Teikyo University School of Medicine University Hospital, Mizonokuchi.


A double-blind, comparative study was performed on the usefulness of rinse containing miconazole nitrate(COFRM)compared to rinse without the reagent for the treatment of dandruff, when together with shampoo containing miconazole nitrate (COF). This study showed that both COFR and COFRM had about 80% utility. On the other hand, though it was not significant, enhanced improvement of itching by COFRM compared to COFR was detected 2 weeks after start of the examination. These results suggest that by mixing the miconazole nitrate with not only the shampoo but also rinse, the reagent more certainly remained on the scalp so that proliferation of the Malassezia was disturbed. Therefore, the effectiveness could clearly be more practically felt at the early stage. Collectively, these results indicate that COFRM was a useful rinse that allowed the effect to actually be felt in the short-term when used together with COF and contributed to the compliance improvement.

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