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Rheumatology (Oxford). 2012 Mar;51(3):403-12. doi: 10.1093/rheumatology/ker215. Epub 2011 Sep 3.

Dynamic regulation of glucocorticoid signalling in health and disease.

Author information

1
University of Bristol, Bristol BS1 3NY, UK.

Abstract

Activation of the glucocorticoid receptor (GR) by endogenous and synthetic glucocorticoids regulates hundreds of genes to control regulatory networks in development, metabolism, cognition and inflammation. Elucidation of the mechanisms that regulate glucocorticoid action has highlighted the dynamic nature of hormone signalling and provides novel insights into genomic glucocorticoid actions. The major factors that regulate GR function include chromatin structure, epigenetics, genetic variation and the pattern of glucocorticoid hormone secretion. We review our current understanding of the mechanisms that contribute to GR signalling and how these contribute to glucocorticoid sensitivity, resistance and side effects.

PMID:
21891790
PMCID:
PMC3281495
DOI:
10.1093/rheumatology/ker215
[Indexed for MEDLINE]
Free PMC Article

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