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Clin Perinatol. 2011 Sep;38(3):407-21. doi: 10.1016/j.clp.2011.06.001.

Abruption-associated prematurity.

Author information

1
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520-8063, USA. christina.han@yale.edu

Abstract

Chronic, subacute decidual hemorrhage (ie, abruptio placenta and retrochorionic hematoma formation) is an important contributor to preterm parturition. Such hemorrhage induces thrombin from decidual tissue factor, which plays a pivotal role in the development of preterm premature rupture of membranes and preterm delivery by acting through protease-activated receptors to promote the production of pro-inflammatory cytokines, and matrix-degrading metalloproteinases. Severe, acute abruption can lead to maternal and fetal mortality. Current management of abruption is individualized based on severity of disease, underlying etiology, and gestational age.

PMID:
21890016
PMCID:
PMC3175371
DOI:
10.1016/j.clp.2011.06.001
[Indexed for MEDLINE]
Free PMC Article

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