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Curr Opin Struct Biol. 2011 Oct;21(5):597-602. doi: 10.1016/j.sbi.2011.08.006. Epub 2011 Sep 1.

Emerging themes in cryptococcal capsule synthesis.

Author information

1
Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA.

Abstract

Cryptococcus neoformans, a basidiomycete yeast and opportunistic pathogen, expends significant biosynthetic effort on construction of a polysaccharide capsule with a radius that may be many times that of the cell. Beyond posing a stimulating challenge in terms of defining biosynthetic pathways, the capsule is required for this yeast to cause fatal disease. This combination has focused the attention of researchers on this system. Here we briefly review two aspects of the rapidly advancing field of capsule synthesis: the extensive variation that occurs in capsule polymers and the regulation of capsule biosynthesis.

PMID:
21889889
PMCID:
PMC3189294
DOI:
10.1016/j.sbi.2011.08.006
[Indexed for MEDLINE]
Free PMC Article

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