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Endocrinol Metab Clin North Am. 2011 Sep;40(3):533-47, viii. doi: 10.1016/j.ecl.2011.05.007. Epub 2011 Jul 7.

Androgens and breast cancer in men and women.

Author information

1
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1103, USA. dimitrac@mail.nih.gov

Abstract

Abundant clinical evidence suggests that androgens normally inhibit mammary epithelial proliferation and breast growth. Clinical and nonhuman primate studies support the notion that androgens inhibit mammary proliferation and, thus, may protect from breast cancer. On the other hand, administration of conventional estrogen treatment suppresses endogenous androgens and may, thus, enhance estrogenic breast stimulation and possibly breast cancer risk. Addition of testosterone to the usual hormone therapy regimen may diminish the estrogen/progestin increase in breast cancer risk, but the impact of this combined use on mammary gland homeostasis still needs evaluation.

PMID:
21889719
DOI:
10.1016/j.ecl.2011.05.007
[Indexed for MEDLINE]

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