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Int J Biol Macromol. 2012 Jan 1;50(1):1-6. doi: 10.1016/j.ijbiomac.2011.08.016. Epub 2011 Aug 25.

Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein.

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Department of Chemistry, Fudan University, Shanghai 200433, China.


The cAMP receptor protein (CRP) requires cAMP for an allosteric change and regulates more than 150 genes in Escherichia coli. In this study, the modular half of cAMP receptor protein was used to investigate the allosteric signal transmission pathway induced by cAMP binding. The activation of CRP upon cAMP binding is indicated to be realignment of the two subunits within the CRP dimer. The interaction of loop 3 and Phe136 do not involve in signal transmission.

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