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Sci Pharm. 2011 Jul-Sep;79(3):615-21. doi: 10.3797/scipharm.1104-16. Epub 2011 Jun 9.

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1).

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1
School of Biological Sciences, Queen's University Belfast, BT9 5AG, Northern Ireland, United Kingdom.

Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P<0.05-0.001). Oral gavage of OLE and GLN modestly increased plasma GLP-1 concentrations (48% and 41%, respectively), but did not lower glycaemic excursions. OLE and GLN are potent stimulators of GLP-1 secretion both in vitro and in vivo and chronic studies should assess their suitability as nutritional therapies for type 2 diabetes.

KEYWORDS:

Casein; Chlorogenic acid; Diabetes; Glucose; Glutamine; Hormone; Olive leaf extract; Secretion

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