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Curr Neuropharmacol. 2011 Mar;9(1):151-4. doi: 10.2174/157015911795017119.

Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese.

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Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.


Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.


Methamphetamine-induced psychosis; endothelial nitric oxide synthase (NOS3); gene-based case-control association study.

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