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Nat Rev Neurosci. 2011 Sep 2;12(10):553-69. doi: 10.1038/nrn3086.

Linking neural activity and molecular oscillations in the SCN.

Author information

1
Laboratory of Circadian and Sleep Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, California 90024, USA. CColwell@mednet.ucla.edu

Abstract

Neurons in the suprachiasmatic nucleus (SCN) function as part of a central timing circuit that drives daily changes in our behaviour and underlying physiology. A hallmark feature of SCN neuronal populations is that they are mostly electrically silent during the night, start to fire action potentials near dawn and then continue to generate action potentials with a slow and steady pace all day long. Sets of currents are responsible for this daily rhythm, with the strongest evidence for persistent Na(+) currents, L-type Ca(2+) currents, hyperpolarization-activated currents (I(H)), large-conductance Ca(2+) activated K(+) (BK) currents and fast delayed rectifier (FDR) K(+) currents. These rhythms in electrical activity are crucial for the function of the circadian timing system, including the expression of clock genes, and decline with ageing and disease. This article reviews our current understanding of the ionic and molecular mechanisms that drive the rhythmic firing patterns in the SCN.

PMID:
21886186
PMCID:
PMC4356239
DOI:
10.1038/nrn3086
[Indexed for MEDLINE]
Free PMC Article

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