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J Pediatr. 2012 Jan;160(1):19-24.e4. doi: 10.1016/j.jpeds.2011.07.038. Epub 2011 Aug 31.

Replication of a genome-wide association study of birth weight in preterm neonates.

Author information

1
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Abstract

OBJECTIVE:

To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm population. Both markers were associated with birth weight in a term population in a recent genome-wide association study of Freathy et al.

STUDY DESIGN:

A meta-analysis of mother and infant samples was performed for associations of rs900400 and rs9883204 with birth weight in 393 families from the US, 265 families from Argentina, and 735 mother-infant pairs from Denmark. Z-scores adjusted for infant sex and gestational age were generated for each population separately and regressed on allele counts. Association evidence was combined across sites by inverse-variance weighted meta-analysis.

RESULTS:

Each additional C allele of rs900400 (LEKR1/CCNL1) in infants was marginally associated with a 0.069 SD lower birth weight (95% CI, -0.159 to 0.022; P = .068). This result was slightly more pronounced after adjusting for smoking (P = .036). No significant associations were identified with rs9883204 or in maternal samples.

CONCLUSIONS:

These results indicate the potential importance of this marker on birth weight regardless of gestational age.

PMID:
21885063
PMCID:
PMC3237813
DOI:
10.1016/j.jpeds.2011.07.038
[Indexed for MEDLINE]
Free PMC Article

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