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Cell Stem Cell. 2011 Sep 2;9(3):187-92. doi: 10.1016/j.stem.2011.08.005.

Breaking the cell cycle of HSCs by p57 and friends.

Author information

1
Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

Abstract

The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.

PMID:
21885016
DOI:
10.1016/j.stem.2011.08.005
[Indexed for MEDLINE]
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