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Mol Cell. 2011 Sep 2;43(5):695-7. doi: 10.1016/j.molcel.2011.08.015.

A new twist on clock protein phosphorylation: a conformational change leads to protein degradation.

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1
Department of Biology, National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 02454, USA.

Abstract

Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces a conformational change, which can account for its temporally gated degradation.

PMID:
21884970
DOI:
10.1016/j.molcel.2011.08.015
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