Format

Send to

Choose Destination
See comment in PubMed Commons below
J Dtsch Dermatol Ges. 2011 Sep;9(9):666-9. doi: 10.1111/j.1610-0387.2011.07636.x. Epub 2011 Mar 29.

Typically atypical: histiocytoid Sweet syndrome, associated with malignancy.

[Article in English, German]

Author information

1
Department of Dermatology, Venerology and Allergology, University of Würzburg, Germany. huenermund_a@klinik.uni-wuerzburg.de

Abstract

Sweet syndrome (acute febrile neutrophilic dermatosis) is characterized by a dramatic onset of high fever, neutrophilia and typical skin lesions. About 20 % of patients have an associated malignancy, most commonly hematologic diseases. Chronic and paucisymptomatic manifestations of Sweet syndrome may be misdiagnosed or misinterpreted as harmless, resulting in delayed diagnosis. "Atypical" manifestations are especially suspicious for associated malignancies. This is demonstrated by a 39-year old patient with chronic and afebrile disease who was referred to our clinic only after symptoms had persisted for several months. By that point, an underlying nodular lymphocyte predominant Hodgkin's lymphoma had already reached an advanced stage. Skin biopsies revealed dermal infiltrates of histiocytoid cells of myelogenous origin, supporting a diagnosis of histiocytoid Sweet syndrome. Specific cutaneous infiltrates associated with myelogenous leukemia were ruled out.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center