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Immunol Rev. 2011 Sep;243(1):91-8. doi: 10.1111/j.1600-065X.2011.01052.x.

RIG-I-like receptors: cytoplasmic sensors for non-self RNA.

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Laboratory of Molecular Genetics, Institute for Virus, Research, Kyoto University, Sakyo-ku, Kyoto, Japan.


Viral infection results in the generation of non-self RNA species in the cells, which is recognized by retinoic acid inducible gene-I-like receptors (RLRs), and initiates innate antiviral responses, including the production of proinflammatory cytokines and type I interferon. In this review, we summarize reports on virus-specificity of RLRs, structures of non-self RNA patterns, structural biology of RLRs, and the signaling adapter molecules involved in antiviral innate immunity.

[Indexed for MEDLINE]

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