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BJOG. 2011 Nov;118(12):1446-54. doi: 10.1111/j.1471-0528.2011.03045.x. Epub 2011 Aug 22.

Perinatal morbidity associated with late preterm deliveries compared with deliveries between 37 and 40 weeks of gestation.

Author information

1
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 94143-0132, USA. yvecheng@hotmail.com

Erratum in

  • BJOG. 2011 Dec;118(13):1687. Hallaron, D R [corrected to Halloran, D R].

Abstract

OBJECTIVE:

To estimate the risk of short-term complications in neonates born between 34 and 36 weeks of gestation.

DESIGN:

This is a retrospective cohort study.

SETTING:

Deliveries in 2005 in the USA.

POPULATION:

Singleton live births between 34 and 40 weeks of gestation.

METHODS:

Gestational age was subgrouped into 34, 35, 36 and 37-40 completed weeks of gestation. Statistical comparisons were performed using chi-square test and multivariable logistic regression models, with 37-40 weeks of gestation designated as referent.

MAIN OUTCOME MEASURES:

Perinatal morbidities, including 5-minute Apgar scores, hyaline membrane disease, neonatal sepsis/antibiotics use, and admission to the intensive care unit.

RESULTS:

In all, 175,112 neonates were born between 34 and 36 weeks in 2005. Compared with neonates born between 37 and 40 weeks, neonates born at 34 weeks had higher odds of 5-minute Apgar <7 (adjusted odds ratio [aOR] 5.51, 95% CI 5.16-5.88), hyaline membrane disease (aOR 10.2, 95% CI 9.44-10.9), mechanical ventilation use >6 hours (aOR 9.78, 95% CI 8.99-10.6) and antibiotic use (aOR 9.00, 95% CI 8.43-9.60). Neonates born at 35 weeks were similarly at risk of morbidity, with higher odds of 5-minute Apgar <7 (aOR 3.42, 95% CI 3.23-3.63), surfactant use (aOR 3.74, 95% CI 3.21-4.22), ventilation use >6 hours (aOR 5.53, 95% CI 5.11-5.99) and neonatal intensive-care unit admission (aOR 11.3, 95% CI 11.0-11.7). Neonates born at 36 weeks remain at higher risk of morbidity compared with deliveries at 37-40 weeks of gestation.

CONCLUSIONS:

Although the risk of undesirable neonatal outcomes decreases with increasing gestational age, the risk of neonatal complications in late preterm births remains higher compared with infants delivered at 37-40 weeks of gestation.

PMID:
21883872
PMCID:
PMC3403292
DOI:
10.1111/j.1471-0528.2011.03045.x
[Indexed for MEDLINE]
Free PMC Article

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