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Dermatol Surg. 2011 Dec;37(12):1721-9. doi: 10.1111/j.1524-4725.2011.02123.x. Epub 2011 Aug 24.

Enhanced effect of platelet-rich plasma containing a new carrier on hair growth.

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Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.



Treatments for alopecia are in high demand, but not all are safe and reliable. Dalteparin and protamine microparticles (D/P MPs) can effectively carry growth factors (GFs) in platelet-rich plasma (PRP).


To identify the effects of PRP-containing D/P MPs (PRP&D/P MPs) on hair growth.


Participants were 26 volunteers with thin hair who received five local treatments of 3 mL of PRP&D/P MPs (13 participants) or PRP and saline (control, 13 participants) at 2- to 3-week intervals and were evaluated for 12 weeks. Injected areas comprised frontal or parietal sites with lanugo-like hair. Experimental and control areas were photographed. Consenting participants underwent biopsies for histologic examination.


D/P MPs bind to various GFs contained in PRP. Significant differences were seen in hair cross-section but not in hair numbers in PRP and PRP&D/P MP injections. The addition of D/P MPs to PRP resulted in significant stimulation in hair cross-section. Microscopic findings showed thickened epithelium, proliferation of collagen fibers and fibroblasts, and increased vessels around follicles.


PRP&D/P MPs and PRP facilitated hair growth but D/P MPs provided additional hair growth. The authors have indicated no significant interest with commercial supporters.

[Indexed for MEDLINE]

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