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J Clin Periodontol. 2011 Oct;38(10):894-901. doi: 10.1111/j.1600-051X.2011.01764.x. Epub 2011 Aug 24.

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis.

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1
Department of Restorative Dentistry, Cork University Dental School and Hospital, Wilton, Ireland. e.allen@ucc.ie

Abstract

AIM:

To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.

MATERIALS AND METHODS:

A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.

RESULTS:

pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.

CONCLUSION:

Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

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