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J Am Geriatr Soc. 2011 Sep;59(9):1686-91. doi: 10.1111/j.1532-5415.2011.03573.x. Epub 2011 Aug 30.

Contribution of multiple chronic conditions to universal health outcomes.

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  • 1Department of Medicine, School of MedicineSchool of Public Health, Yale University, New Haven, Connecticut 06520, USA.

Erratum in

  • J Am Geriatr Soc. 2011 Nov;59(11):2196.



To determine the relative effect of five chronic conditions on four representative universal health outcomes.




Cardiovascular Health Study.


Five thousand two hundred and ninety-eight community-living participants aged 65 and older.


Multiple regression and Cox models were used to determine the effect of heart failure (HF), chronic obstructive pulmonary disease (COPD), osteoarthritis, depression, and cognitive impairment on self-rated health, 12 basic and instrumental activities of daily living (ADLs and IADLs), six-item symptom burden scale, and death.


Each condition adversely affected self-rated health (P < .001) and ADLs and IADLs (P < .001). For example, persons with HF performed 0.70 ± 0.08 fewer ADLs and IADLs than those without; persons with depression and persons with cognitive impairment performed 0.59 ± 0.04 and 0.58 ± 0.06 fewer activities, respectively, than those without these conditions. Depression, HF, COPD, and osteoarthritis were associated with 1.18 ± 0.04, 0.40 ± 0.08, 0.40 ± 0.05, and 0.57 ± 0.03 more symptoms, respectively, in individuals with these conditions than in those without. HF (hazard ratio (HR) = 2.84, 95% confidence interval (CI) = 1.97-4.10), COPD (2.62, 95% CI = 1.94-3.53), cognitive impairment (2.05, 95% CI = 1.47-2.85), and depression (1.47, 95% CI = 1.08-2.01) were each associated with death within 2 years. Several paired combinations of conditions had synergistic effects on ADLs and IADLs. For example, individuals with HF plus depression performed 2.0 fewer activities than persons with neither condition, versus the 1.3 fewer activities expected from adding the effects of the two conditions together.


Universal health outcomes may provide a common metric for measuring the effects of multiple conditions and their treatments. The varying effects of the conditions across universal outcomes could inform care priorities.

© 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society.

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