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J Infect Dis. 2011 Oct 1;204(7):1134-7. doi: 10.1093/infdis/jir461.

IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis.

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1
Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Abstract

The mechanisms underlying the failure to contain the growth of Leishmania parasites in human visceral leishmaniasis (VL) are not understood. L donovani amastigotes were quantified in cultured splenic aspirate cells to assess the function of IL-10 in lesional tissue ex vivo. In 67 patients with active VL, IL-10 neutralization promoted parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change. The splenic cells secreted increased levels of both tumor necrosis factor α (TNFα) and interferon γ (IFNγ) under IL-10-neutralizing conditions. These findings provide direct support for targeting IL-10 as an approach to therapy in human VL.

PMID:
21881130
PMCID:
PMC3164427
DOI:
10.1093/infdis/jir461
[Indexed for MEDLINE]
Free PMC Article
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