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EMBO J. 2011 Aug 31;30(17):3475-80. doi: 10.1038/emboj.2011.255.

Protein export at the ER: loading big collagens into COPII carriers.

Author information

1
ICREA, Barcelona, Spain. vivek.malhotra@crg.eu

Abstract

COPII vesicles mediate the export of secretory cargo from endoplasmic reticulum (ER) exit sites. However, of 60-90 nm diameter COPII vesicles are too small to accommodate secreted molecules such as the collagens. The ER exit site-located proteins TANGO1 and cTAGE5 are required for the transport of collagens and therefore provide a means to understand the export of big cargo and the mechanism of COPII carrier size regulation commensurate with cargo dimensions.

PMID:
21878990
PMCID:
PMC3181478
DOI:
10.1038/emboj.2011.255
[Indexed for MEDLINE]
Free PMC Article

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