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Pediatr Radiol. 2012 May;42(5):627-31. doi: 10.1007/s00247-011-2236-7. Epub 2011 Aug 30.

Anaplastic large cell lymphoma of the esophagus in a pediatric patient.

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Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.


We report a 3-year-old boy who initially presented with abdominal pain and was subsequently found to have an esophageal perforation. The child did not respond to conservative management, and subsequent lymphadenopathy led to a lymph node biopsy demonstrating an anaplastic lymphoma kinase (ALK)+ anaplastic large cell lymphoma. Esophageal perforation and thickening is most commonly seen in children with a history of esophageal intervention or foreign body/caustic ingestion. Esophageal involvement in children with non-Hodgkin lymphoma (NHL) has not, to our knowledge, been reported in the literature. This case illustrates an unusual presentation of pediatric NHL.

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