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Neurol Res Int. 2011;2011:563784. doi: 10.1155/2011/563784. Epub 2011 Aug 24.

Huntington's Disease: An Immune Perspective.

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Centre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UK.


Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

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