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Neuro Endocrinol Lett. 2011;32(4):437-41.

Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation.

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1
Department of Neurology and Centre of Clinical Neuroscience, Charles University, Prague, Czech Republic.

Abstract

OBJECTIVES:

Weight gain has been reported in patients with Parkinson's disease (PD) treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). To evaluate the influence of STN-DBS on weight changes, we studied food-related hormones.

DESIGN:

Anthropometric parameters and food-related hormones (leptin, adiponectin, resistin, ghrelin, cortisol, insulin, and thyroid stimulating hormone) were measured in 27 patients with STN-DBS during a 12 month period following electrode implantation.

RESULTS:

Besides marked motor improvements on STN-DBS, PD patients significantly gained weight. The mean weight gain at 12 months was 5.2±(SD)5.8 kg. A significant decrease in cortisol levels compared to baseline appeared at month 2 and persisted at 12 months (p<0.01, corrected), with no significant changes in other hormones tested.

CONCLUSIONS:

Changes in peripheral food-related hormones do not appear to cause weight gain in PD patients. Direct effects of STN-DBS on hypothalamic catabolic/anabolic peptide balance remain hypothetical and necessitate further elucidation.

PMID:
21876505
[Indexed for MEDLINE]
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