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Dement Geriatr Cogn Disord. 2011;32(2):79-93. doi: 10.1159/000330757. Epub 2011 Aug 26.

A systematic literature review of cerebrospinal fluid biomarkers in delirium.

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1
Edinburgh Delirium Research Group, Geriatric Medicine, Division of Health Sciences, School of Clinical Sciences and Community Health, UK. roanna.hall @ ed.ac.uk

Abstract

BACKGROUND:

Cerebrospinal fluid (CSF) analysis has great potential to advance understanding of delirium pathophysiology.

METHODS:

A systematic literature review of CSF studies of DSM or ICD delirium was performed.

RESULTS:

In 8 studies of 235 patients, delirium was associated with: elevated serotonin metabolites, interleukin-8, cortisol, lactate and protein, and reduced somatostatin, β-endorphin and neuron-specific enolase. Elevated acetylcholinesterase predicted poor outcome after delirium and higher dopamine metabolites were associated with psychotic features.

CONCLUSIONS:

No clear conclusions emerged, but the current literature suggests multiple areas for further investigation with more detailed studies.

PMID:
21876357
DOI:
10.1159/000330757
[Indexed for MEDLINE]
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