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Bioorg Med Chem Lett. 2011 Oct 1;21(19):5750-2. doi: 10.1016/j.bmcl.2011.08.015. Epub 2011 Aug 10.

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Author information

1
Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland BT52 1SA, United Kingdom.

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

PMID:
21875807
DOI:
10.1016/j.bmcl.2011.08.015
[Indexed for MEDLINE]

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