Acquired hemophilia A

Adv Clin Chem. 2011:54:71-80. doi: 10.1016/b978-0-12-387025-4.00003-0.

Abstract

Acquired hemophilia A is a rare but often life-threatening hemorrhagic disorder characterized by an autoantibody directed against coagulation factor VIII. Fifty per cent of cases are idiopathic whereas the remaining 50% are associated with pregnancy, autoimmune conditions, malignancies and drugs. In this review the actual knowledge on diagnostic and therapeutic aspects of this disease will be summarized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hemophilia A / diagnosis
  • Hemophilia A / etiology
  • Hemophilia A / therapy*
  • Humans

Supplementary concepts

  • Factor 8 deficiency, acquired