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Am J Geriatr Psychiatry. 2011 Sep;19(9):825-9. doi: 10.1097/JGP.0b013e31820eeb21.

Association between tryptophan hydroxylase-2 gene and late-onset depression.

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  • 1Laboratório de Neurociência, INCT-Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Departamento de Saúde Mental, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena, 190, Belo Horizonte-MG, 30130, Brazil. patriciabiomol@yahoo.com.br

Abstract

OBJECTIVE:

The aim of this study was to examine the association between polymorphisms (SNP) in the tryptophan hydroxylase-2 (TPH2) gene and late-onset depression (LOD) in the Brazilian population.

METHODS:

We genotyped 8 tag SNPs in the TPH2 gene in 84 outpatients with LOD and 79 individuals belonging to the comparison group to investigate an association between the TPH2 gene and LOD.

RESULTS:

Our findings suggested an association between tag SNP rs4565946 heterozygous C/T (p = 0.034; χ2 = 6.7; df = 2) and decreased risk of LOD. The tag SNP rs11179000 ancestral homozygous A/A (p = 0.025; χ2 = 7.3; df = 2) and increase risk of LOD and allelic association of ancestral allele A and increase risk of LOD was demonstrated (p = 0.005; χ2 = 7.8; df = 1).

CONCLUSION:

We found the statistically significant association between two tag SNPs and LOD. Our results support the hypothesis that the TPH2 gene is associated with LOD.

PMID:
21873838
DOI:
10.1097/JGP.0b013e31820eeb21
[PubMed - indexed for MEDLINE]
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