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J Biol Chem. 2011 Oct 7;286(40):34479-85. doi: 10.1074/jbc.R111.290585. Epub 2011 Aug 26.

Termination of protein synthesis in mammalian mitochondria.

Author information

1
Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

Abstract

All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.

PMID:
21873426
PMCID:
PMC3186377
DOI:
10.1074/jbc.R111.290585
[Indexed for MEDLINE]
Free PMC Article

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