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  • PMID: 21872504 was deleted because it is a duplicate of PMID: 22677018
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jun;113(6):728-33. doi: 10.1016/j.tripleo.2011.05.039. Epub 2011 Aug 26.

Dental stem cells for craniofacial tissue engineering.

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Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal.


This article focuses on the biological characterization and discussion of the potential application of oral-derived adult stem cells for craniofacial tissue engineering applications. The authors reviewed experimental (in vitro and in vivo) and clinical reports regarding the isolation, characterization, modulation, and translational clinical application of human precursor cell populations derived from postnatal dental tissues. Five different human dental stem/progenitor cell populations have been isolated and characterized. These postnatal populations present mesenchymal stem cell-like characteristics and enjoy forceful capabilities regarding the differentiation into odontogenic/osteogenic lineages, supporting evidence--in preclinical and clinical trials--for the regeneration of oral/dental tissues.

[Indexed for MEDLINE]

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