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Trends Microbiol. 2011 Oct;19(10):472-82. doi: 10.1016/j.tim.2011.07.006. Epub 2011 Aug 25.

Combined phylogenetic and genomic approaches for the high-throughput study of microbial habitat adaptation.

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1
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Abstract

High-throughput sequencing technologies provide new opportunities to address longstanding questions about habitat adaptation in microbial organisms. How have microbes managed to adapt to such a wide range of environments, and what genomic features allow for such adaptation? We review recent large-scale studies of habitat adaptation, with emphasis on those that utilize phylogenetic techniques. On the basis of current trends, we summarize methodological challenges faced by investigators, and the tools, techniques and analytical approaches available to overcome them. Phylogenetic approaches and detailed information about each environmental sample will be crucial as the ability to collect genome sequences continues to expand.

PMID:
21872475
PMCID:
PMC3184378
DOI:
10.1016/j.tim.2011.07.006
[Indexed for MEDLINE]
Free PMC Article
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