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Epilepsy Res. 2012 Jul;100(3):286-94. doi: 10.1016/j.eplepsyres.2011.04.016. Epub 2011 Aug 26.

Neuroprotection in metabolism-based therapy.

Author information

1
Johns Hopkins University, Neurology, 600 N. Wolfe St., Meyer 2-147, Baltimore, MD 21287, USA. Ahartma2@jhmi.edu

Abstract

Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating the use of different forms of metabolism-based therapy in human trials of Alzheimer disease and Parkinson disease are discussed. Animal and in vitro studies have shed light on metabolism-based therapy's mechanisms in these diseases, as well as ALS, aging, ischemia, trauma and mitochondrial cytopathies. Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy).

PMID:
21872441
PMCID:
PMC3245363
DOI:
10.1016/j.eplepsyres.2011.04.016
[Indexed for MEDLINE]
Free PMC Article

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