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Am J Obstet Gynecol. 2011 Nov;205(5):478.e1-7. doi: 10.1016/j.ajog.2011.06.069. Epub 2011 Jun 25.

Is the treatment of CIN 2 always necessary in women under 25 years old?

Author information

1
Department of Obstetrics and Gynecology, Christchurch School of Medicine, University of Otago, Christchurch, New Zealand. mcabr965@student.otago.ac.nz

Abstract

OBJECTIVE:

The purpose of this study was to review the outcome of conservatively managed cervical intraepithelial neoplasia (CIN) 2 in women <25 years old.

STUDY DESIGN:

This was a retrospective review that included women who were <25 years old with biopsy proven CIN2 between 2005 and 2009. Analysis was performed that compared women who had immediate treatment with women whose treatment was deferred >4 months. The primary outcome measure was spontaneous regression of CIN2. Secondary outcomes were treatment rates and loss to follow-up evaluation.

RESULTS:

Of the 452 women who were identified, 256 women (57%) received immediate treatment; 157 women (35%) met the definition for conservative management, and 39 women (9%) had unknown subsequent management. Of the 157 women who were managed conservatively, 98 women (62%) showed spontaneous regression, with a median of 8 months observation. No conservatively managed women progressed to cancer.

CONCLUSION:

Based on the 62% regression rate in this study, routine treatment may not be necessary for all women with CIN2 who are <25 years old.

PMID:
21872201
DOI:
10.1016/j.ajog.2011.06.069
[Indexed for MEDLINE]

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