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J Card Fail. 2011 Sep;17(9):755-63. doi: 10.1016/j.cardfail.2011.04.016.

Depressive symptom trajectory predicts 1-year health-related quality of life in patients with heart failure.

Author information

1
University of Kentucky College of Nursing, Lexington, Kentucky 40536-0232, USA. rdekker@uky.edu

Abstract

BACKGROUND:

One-third of patients with heart failure (HF) experience depressive symptoms that adversely affect health-related quality of life (HRQOL). We aimed to describe depressive symptom trajectory and determine whether a change in depressive symptoms predicts subsequent HRQOL.

METHODS AND RESULTS:

The sample consisted of 256 inpatients and outpatients with HF. Depressive symptoms were measured at baseline and 3 or 6 months with the Patient Health Questionnaire (PHQ-9). The Minnesota Living with HF Questionnaire was used to assess HRQOL at baseline, 3 to 6 months, and 1 year. Based on baseline and 3- to 6-month PHQ-9 scores, patients were categorized as depressive symptom-free (64%), depressive symptoms improved (15%), depressive symptoms developed (6%), or persistent depressive symptoms (15%). The groups differed in 1-year HRQOL levels (F = 36, P < .001); patients who were depressive symptom-free or whose depressive symptoms improved had better 1-year HRQOL than patients with persistent depressive symptoms (Tukey honestly significant difference, P < .01). Change in depressive symptoms was the strongest predictor of 1-year HRQOL (standardized β = .42, P < .001), after controlling for functional status, demographics, and clinical variables.

CONCLUSIONS:

We found the trajectory of depressive symptoms predicts future HRQOL. Research is needed to determine whether interventions targeting depressive symptoms improve HRQOL in patients with HF.

PMID:
21872146
PMCID:
PMC3164519
DOI:
10.1016/j.cardfail.2011.04.016
[Indexed for MEDLINE]
Free PMC Article
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