Format

Send to

Choose Destination
Blood. 2011 Oct 27;118(17):4609-19. doi: 10.1182/blood-2010-12-323972. Epub 2011 Aug 25.

JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow.

Author information

1
Centre de Recherche en Cancérologie de Marseille, Unité Mixle de Recherche, Marseille, France.

Abstract

In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice. We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1α BM content in jam-b(-/-) mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment.

PMID:
21868569
DOI:
10.1182/blood-2010-12-323972
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center