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J Pediatr. 2012 Feb;160(2):314-9. doi: 10.1016/j.jpeds.2011.07.012. Epub 2011 Aug 25.

Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.

Author information

1
Department of Pediatrics, University of South Florida, St. Petersburg, FL 33701, USA. tmurphy@health.usf.edu

Abstract

OBJECTIVE:

To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).

STUDY DESIGN:

Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies.

RESULTS:

Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/adenoidectomies, evidence of group A streptococcal infection, and clumsiness.

CONCLUSION:

The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/tics.

PMID:
21868033
PMCID:
PMC3227761
DOI:
10.1016/j.jpeds.2011.07.012
[Indexed for MEDLINE]
Free PMC Article

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