Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2011 Sep 9;412(4):590-5. doi: 10.1016/j.bbrc.2011.08.003. Epub 2011 Aug 16.

Biomarker signatures of mitochondrial NDUFS3 in invasive breast carcinoma.

Author information

1
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Abstract

We present evidence for potential biomarker utility of a mitochondrial complex I subunit, (NDUFS3) in discriminating normal and highly invasive breast carcinoma specimens obtained from clinical patients. Besides being a robust indicator of breast cancer aggressiveness, NDUFS3 also shows clear signatures of a hypoxia/necrosis marker in invasive ductal carcinoma specimens. Statistically significant positive correlation was observed between nuclear grade and NDUFS3 expression level in the tumor specimens analyzed. We support these findings with a plausible mechanism involving mitochondrial complex I assembly defects and/or redox buffering induced mitochondrial dysfunction during the process of cancer cell transformation. From a clinical standpoint, this novel observation adds value in augmenting the current receptor-based biomarkers for better accuracy in diagnosis and predicting survival rate in patients with breast carcinoma.

PMID:
21867691
PMCID:
PMC3171595
DOI:
10.1016/j.bbrc.2011.08.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center